HELX vs. IBBQ ETF Comparison

Comparison of Franklin Genomic Advancements ETF (HELX) to Invesco Nasdaq Biotechnology ETF (IBBQ)

HELX

Franklin Genomic Advancements ETF

HELX Description

Seeks capital appreciation by investing in innovative companies related to genomic-based technologies designed to enhance the quality of life. Provides access to companies benefitting from or facilitating the use of new research including DNA sequencing, gene editing and personalized medicine Uses bottom-up fundamental research conducted by dedicated, industry-specific analysts to identify disruptive business models at the right stage for investment Actively managed by a seasoned portfolio management team that is based in Silicon Valley and has a long history of investing in the craft of innovation

Grade (RS Rating)

Last Trade

$29.53

Average Daily Volume

2,580

Number of Holdings ^*

* may have additional holdings in another (foreign) market

IBBQ

Invesco Nasdaq Biotechnology ETF

IBBQ Description

The investment seeks to track the investment results (before fees and expenses) of the Nasdaq Biotechnology Index ®. The fund generally will invest at least 90% of its total assets in the securities that comprise the index. Strictly in accordance with its guidelines and mandated procedures, Nasdaq compiles the underlying index, which is a modified market capitalization weighted index that is designed to measure the performance of securities listed on the Nasdaq Stock Market that are classified as either biotechnology or pharmaceutical companies. The index may include securities of large-, mid- and small-capitalization companies. The fund is non-diversified.

Grade (RS Rating)

Last Trade

$22.29

Average Daily Volume

17,582

Number of Holdings ^*

195

* may have additional holdings in another (foreign) market

Performance

Period	HELX	IBBQ
30 Days	-5.99%	-6.27%
60 Days	-10.44%	-8.87%
90 Days	-11.92%	-8.76%
12 Months	6.42%	17.68%

28 Overlapping Holdings

Symbol	Grade	Weight in HELX	Weight in IBBQ	Overlap
ALNY	D	1.98%	3.26%	1.98%
AZN	F	2.34%	3.97%	2.34%
BBIO	F	0.91%	0.48%	0.48%
BEAM	D	1.03%	0.21%	0.21%
BMRN	F	0.2%	1.3%	0.2%
BNTX	C	2.21%	1.05%	1.05%
CRNX	C	0.25%	0.47%	0.25%
CRSP	D	0.5%	0.43%	0.43%
DVAX	C	0.53%	0.17%	0.17%
FDMT	F	0.1%	0.05%	0.05%
INSM	C	2.08%	1.23%	1.23%
IONS	F	2.1%	0.54%	0.54%
KRYS	C	4.7%	0.53%	0.53%
LGND	C	1.27%	0.22%	0.22%
MEDP	D	4.07%	1.04%	1.04%
MRNA	F	0.66%	1.53%	0.66%
NBIX	C	0.94%	1.28%	0.94%
NTLA	F	0.51%	0.15%	0.15%
RARE	F	1.46%	0.44%	0.44%
RCKT	F	1.42%	0.14%	0.14%
REGN	F	4.3%	5.67%	4.3%
RXRX	F	0.69%	0.18%	0.18%
SRPT	F	1.5%	1.08%	1.08%
TWST	F	1.27%	0.23%	0.23%
UTHR	C	2.75%	1.75%	1.75%
VCYT	B	0.56%	0.3%	0.3%
VRTX	D	5.94%	8.34%	5.94%
VYGR	F	0.99%	0.03%	0.03%

HELX Overweight 25 Positions Relative to IBBQ

Symbol	Grade	Weight
NTRA	A	4.64%
LLY	F	4.63%
TMO	F	4.01%
DHR	F	3.99%
CDNS	B	2.34%
CTVA	C	2.29%
CRL	D	2.23%
A	D	2.11%
RVTY	F	2.01%
QGEN	D	1.96%
BRKR	D	1.94%
ICLR	D	1.25%
EXAS	D	1.2%
LH	B	1.15%
IQV	F	1.08%
RGEN	D	1.08%
TECH	F	1.01%
AZTA	D	0.95%
BIO	C	0.59%
DOCS	C	0.51%
CDMO	A	0.51%
AVTR	F	0.46%
BMY	B	0.36%
ARE	F	0.15%
SLP	D	0.11%

HELX Underweight 167 Positions Relative to IBBQ

Symbol	Grade	Weight
GILD	C	-9.95%
AMGN	F	-7.56%
BIIB	F	-2.52%
ILMN	C	-2.32%
ARGX	B	-1.96%
VTRS	A	-1.65%
INCY	C	-1.58%
SNY	F	-1.51%
SMMT	D	-1.43%
RPRX	D	-1.24%
EXEL	B	-1.06%
PCVX	D	-1.04%
RVMD	C	-0.99%
ITCI	C	-0.95%
BGNE	D	-0.91%
ROIV	C	-0.89%
JAZZ	B	-0.81%
ASND	F	-0.79%
MDGL	B	-0.67%
CYTK	F	-0.64%
HALO	F	-0.62%
BPMC	B	-0.61%
NUVL	C	-0.56%
RNA	C	-0.53%
ACLX	C	-0.51%
ALKS	C	-0.5%
ADMA	B	-0.48%
AXSM	B	-0.48%
IMVT	F	-0.42%
GH	B	-0.39%
DNLI	D	-0.39%
RYTM	C	-0.37%
LEGN	D	-0.34%
MRUS	F	-0.34%
APLS	F	-0.34%
XENE	D	-0.33%
AGIO	C	-0.33%
EWTX	C	-0.32%
PTCT	B	-0.32%
DYN	F	-0.31%
FOLD	F	-0.31%
ACAD	C	-0.3%
KYMR	D	-0.29%
SWTX	C	-0.29%
VRNA	B	-0.28%
VCEL	B	-0.28%
IOVA	F	-0.27%
JANX	C	-0.27%
VERA	C	-0.27%
PTGX	D	-0.26%
ARWR	D	-0.25%
GERN	D	-0.24%
IDYA	F	-0.24%
MIRM	B	-0.23%
SRRK	C	-0.23%
KROS	D	-0.23%
AMPH	F	-0.23%
AKRO	B	-0.21%
SUPN	C	-0.21%
MNKD	C	-0.2%
HRMY	D	-0.2%
FTRE	D	-0.19%
NVCR	C	-0.19%
IRON	B	-0.19%
TARS	C	-0.18%
WVE	C	-0.18%
ARVN	F	-0.17%
BCRX	D	-0.16%
NRIX	C	-0.16%
ZLAB	C	-0.15%
TVTX	C	-0.15%
SPRY	C	-0.15%
HROW	D	-0.15%
MYGN	F	-0.15%
OCUL	D	-0.15%
XNCR	B	-0.15%
DAWN	D	-0.14%
SNDX	F	-0.14%
AUPH	B	-0.13%
ARDX	F	-0.13%
NVAX	F	-0.13%
INVA	D	-0.13%
ANIP	F	-0.13%
IMCR	D	-0.13%
KURA	F	-0.13%
ARQT	B	-0.12%
VIR	D	-0.12%
CNTA	B	-0.12%
ELVN	D	-0.12%
GRFS	C	-0.12%
COLL	F	-0.1%
COGT	D	-0.1%
CGEM	F	-0.09%
BCYC	F	-0.09%
ETNB	C	-0.09%
GMAB	F	-0.09%
REPL	D	-0.08%
ADPT	C	-0.08%
PLRX	D	-0.08%
ERAS	C	-0.08%
PRTA	F	-0.08%
EOLS	D	-0.08%
PCRX	C	-0.08%
ABCL	D	-0.08%
CSTL	D	-0.08%
AUTL	F	-0.07%
MRVI	F	-0.07%
AVXL	B	-0.07%
IRWD	F	-0.07%
RLAY	F	-0.07%
ABUS	D	-0.07%
HCM	D	-0.06%
OLMA	F	-0.06%
SANA	F	-0.06%
GLPG	F	-0.06%
CVAC	F	-0.06%
MLYS	F	-0.06%
ANAB	F	-0.06%
HUMA	F	-0.06%
PHAT	F	-0.06%
ORIC	F	-0.06%
TSHA	C	-0.05%
SIGA	F	-0.05%
ARCT	F	-0.05%
XERS	C	-0.05%
PACB	F	-0.05%
TERN	F	-0.05%
RVNC	F	-0.05%
OABI	F	-0.05%
TBPH	B	-0.05%
URGN	F	-0.05%
ALLO	F	-0.05%
RGNX	D	-0.05%
SVRA	F	-0.05%
EYPT	D	-0.05%
YMAB	F	-0.05%
PAHC	C	-0.05%
MGTX	C	-0.05%
THRD	F	-0.05%
LXRX	F	-0.04%
ALEC	F	-0.04%
PRME	F	-0.04%
VERV	F	-0.04%
KALV	F	-0.04%
PGEN	F	-0.03%
BMEA	F	-0.03%
ZNTL	F	-0.03%
ATAI	C	-0.03%
LYEL	F	-0.03%
VNDA	C	-0.03%
ITOS	F	-0.03%
QURE	C	-0.03%
SAGE	F	-0.03%
ACIU	D	-0.03%
ACRS	B	-0.02%
CABA	F	-0.02%
CRBU	D	-0.02%
FULC	F	-0.02%
AMRN	F	-0.02%
EDIT	F	-0.02%
MGNX	F	-0.02%
BLUE	F	-0.01%
ALXO	F	-0.01%
OVID	F	-0.01%
CHRS	D	-0.01%
VTYX	F	-0.01%
RAPT	F	-0.0%