This article is about the uranium mining region near Lake Athabasca. Not to be confused with the drainage basin of the Athabasca River.

The Athabasca Basin is a region in the Canadian Shield of northern Saskatchewan and Alberta Canada. It is best known as the world's leading source of high-grade uranium and currently supplies about 20% of the world's uranium.The basin is located just to the south of Lake Athabasca, west of Wollaston Lake and encloses almost all of Cree Lake. It covers about 100,000 square kilometres in Saskatchewan and a small portion of Alberta. The surface of the basin consists of main sandstone sediment varying from 100 to 1000 metres in depth. The uranium ore is mostly found at the base of this sandstone, at the point where it meets the basement.
On the northern and eastern edges are the communities of Fort Chipewyan in Alberta and Camsell Portage, Stony Rapids, Fond du Lac, Black Lake and Wollaston Lake in Saskatchewan. Much of the Athabasca Basin is within the migratory range of the Beverly caribou herd a major source of sustenance for the Denesuline communities.
Within the basin are the Athabasca Sand Dunes Provincial Park on the south shore of Lake Athabasca and the Carswell crater. The Cluff Lake mine site is located in the crater area.
Points North Landing a permanent supply depot and camp serves the eastern area of the basin.
Road access to the area is provided by Saskatchewan Highway 955 from the village of La Loche on the west side and Saskatchewan Highway 914 and Saskatchewan Highway 905 north of the town of La Ronge on the east side.