OZEM vs. BIS ETF Comparison

Comparison of Roundhill GLP-1 & Weight Loss ETF (OZEM) to ProShares UltraShort Nasdaq Biotechnology (BIS)
OZEM

Roundhill GLP-1 & Weight Loss ETF

OZEM Description

OZEM targets the global weight management industry. The fund invests in companies involved in the development of GLP-1 and other weight loss drugs. GLP-1 agonists seek to aid in weight management by lowering blood sugar levels, reducing appetite, and promoting fullness. The portfolio consists of firms with GLP-1 and weight loss drugs that have been approved by or are currently undergoing Phase I, Phase II, and/or Phase III clinical trials of the US Food & Drug Administration (FDA), or any applicable food and drug regulator for non-US companies. The portfolio is constructed using a proprietary methodology, which selects companies with high levels of thematic relevance based on research of each companys public filings and disclosures. In addition, eligible securities must meet minimum market-cap and liquidity requirements. The actively managed fund, although rebalances portfolio weighting on at least a quarterly basis, may have a heavy concentration on a few names.

Grade (RS Rating)

Last Trade

$26.53

Average Daily Volume

75,803

Number of Holdings *

7

* may have additional holdings in another (foreign) market
BIS

ProShares UltraShort Nasdaq Biotechnology

BIS Description The investment seeks daily investment results that correspond to two times the inverse (-2x) of the daily performance of the Nasdaq Biotechnology Index®. The fund invests in derivatives that ProShare Advisors believes, in combination, should have similar daily return characteristics as two times the inverse (-2x) of the daily return of the index. The index is a modified capitalization weighted index that includes securities of NASDAQ listed companies that are classified as either biotechnology or pharmaceutical according to the Industry Classification Benchmark ("ICB") which also meet other eligibility criteria determined by NASDAQ. It is non-diversified.

Grade (RS Rating)

Last Trade

$17.27

Average Daily Volume

5,046

Number of Holdings *

75

* may have additional holdings in another (foreign) market
Performance
Period OZEM BIS
30 Days 3.59% 0.65%
60 Days -3.04%
90 Days -8.43%
12 Months -15.25%
1 Overlapping Holdings
Symbol Grade Weight in OZEM Weight in BIS Overlap
AMGN B 4.2% 8.14% 4.2%
OZEM Overweight 6 Positions Relative to BIS
Symbol Grade Weight
LLY B 21.39%
NVO C 20.52%
ALT F 3.97%
TERN C 3.32%
VKTX D 3.27%
GPCR F 3.14%
OZEM Underweight 74 Positions Relative to BIS
Symbol Grade Weight
GILD C -7.41%
VRTX B -7.21%
BIIB C -6.12%
ILMN F -5.67%
REGN B -4.13%
INCY C -2.09%
BMRN D -1.91%
ALNY A -1.6%
VTRS F -1.35%
SNY B -1.29%
NBIX C -1.16%
SRPT C -1.15%
NVCR D -1.1%
JAZZ F -1.03%
TECH D -1.02%
IONS B -1.02%
GH C -0.96%
AMRN F -0.85%
MRNA D -0.83%
BGNE F -0.83%
ACAD D -0.81%
ASND C -0.77%
EXEL C -0.73%
ARWR C -0.65%
BLUE F -0.65%
BBIO D -0.51%
ALLK F -0.49%
UTHR B -0.49%
NKTR D -0.48%
SAGE F -0.48%
BPMC B -0.48%
FGEN F -0.47%
DCPH A -0.43%
AGIO C -0.43%
CRSP F -0.42%
RARE F -0.42%
ADPT D -0.42%
MEDP C -0.4%
PTCT D -0.4%
ARGX B -0.4%
AXSM B -0.38%
ALLO F -0.37%
GRFS F -0.36%
IOVA F -0.36%
ALKS D -0.36%
KOD F -0.35%
HALO B -0.35%
QURE F -0.35%
FOLD F -0.32%
APLS F -0.31%
XNCR F -0.26%
MYGN B -0.26%
DNLI C -0.26%
ZLAB F -0.24%
IRWD F -0.24%
ARVN F -0.24%
INSM C -0.23%
FATE F -0.23%
PCRX F -0.22%
GLPG F -0.22%
ITCI C -0.21%
RGNX F -0.21%
ESPR C -0.19%
EDIT F -0.19%
LGND B -0.19%
INVA B -0.18%
VCYT C -0.18%
ALEC F -0.18%
TBPH F -0.17%
YMAB D -0.16%
CHRS F -0.16%
HCM D -0.15%
NGM D -0.15%
SUPN F -0.15%
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