Gm2 Gangliosidosis is a rare, inherited disorder caused by a deficiency of an enzyme called beta-hexosaminidase. This enzyme is responsible for breaking down certain fatty substances in the body called gangliosides. When the enzyme is deficient, these fatty substances accumulate in the brain and other organs, leading to a variety of neurological and physical symptoms. Symptoms of Gm2 Gangliosidosis can include seizures, developmental delays, muscle weakness, vision and hearing loss, and difficulty swallowing.