Netherton Syndrome is a rare genetic disorder that affects the skin, hair, and immune system. It is caused by a mutation in the SPINK5 gene, which is responsible for producing a protein that helps regulate the production of certain skin proteins. Symptoms of Netherton Syndrome include skin that is dry, scaly, and itchy; hair that is sparse, brittle, and easily broken; and an increased risk of infection due to a weakened immune system. Treatment typically involves the use of topical steroids, antibiotics, and moisturizers to help manage the skin and hair symptoms.