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    Orphan Drug ETF List

    ETFs which hold one or more stocks tagged as: Orphan Drug

    Symbol Grade Name Weight
    PBE B PowerShares Dynamic Biotech & Genome 5.46
    FBT B First Trust Amex Biotech Index Fund 5.09
    WDNA C WisdomTree BioRevolution Fund 4.44
    ARKG F ARK Genomic Revolution Multi-Sector ETF 4.18
    XBI B SPDR S&P Biotech ETF 3.81
    IBB B iShares Nasdaq Biotechnology Index Fund 3.74
    BTEC B Principal Healthcare Innovators Index ETF 3.47
    BBP B BioShares Biotechnology Products Fund 3.31
    LABD F Direxion Daily S&P Biotech Bear 3X Shares 3.27
    SBIO C ALPS Medical Breakthroughs ETF 2.71
    HELX B Franklin Genomic Advancements ETF 2.68
    BBC C Virtus LifeSci Biotech Clinical Trials ETF 2.58
    LABU B Direxion Daily S&P Biotech Bull 3X Shares 2.46
    BBH B Market Vectors Biotech ETF 2.04
    IBBQ A Invesco Nasdaq Biotechnology ETF 1.88
    GURU A Global X Top Guru Holdings Index ETF 1.69
    NUMG D NuShares ESG Mid-Cap Growth ETF 1.5
    BIS F ProShares UltraShort Nasdaq Biotechnology 1.34
    CNCR D Loncar Cancer Immunotherapy ETF 1.31
    BIB B ProShares Ultra Nasdaq Biotechnology 1.31
    ETHO C Etho Climate Leadership U.S. ETF 0.9
    VBK D Vanguard Small-Cap Growth ETF 0.87
    TMFX A Motley Fool Next Index ETF 0.83
    ISCG B iShares Morningstar Small-Cap Growth ETF 0.81
    IVOG D Vanguard S&P Mid-Cap 400 Growth ETF 0.72
    SMMV A iShares MSCI USA Small-Cap Min Vol Factor ETF 0.71
    ILDR A First Trust Innovation Leaders ETF 0.68
    IWO B iShares Russell 2000 Growth ETF 0.68
    MDYG D SPDR S&P 400 Mid Cap Growth ETF 0.67
    GDOC A Goldman Sachs Future Health Care Equity ETF 0.65
    VTWG B Vanguard Russell 2000 Growth ETF 0.64
    PEXL B Pacer US Export Leaders ETF 0.63
    QQJG B Invesco ESG NASDAQ Next Gen 100 ETF 0.61
    XPH D SPDR S&P Pharmaceuticals ETF 0.61
    BBMC D JPMorgan BetaBuilders U.S. Mid Cap Equity ETF 0.59
    MIDE D Xtrackers S&P MidCap 400 ESG ETF 0.59
    BKMC D BNY Mellon US Mid Cap Core Equity ETF 0.55
    FFLG A Fidelity Fundamental Large Cap Growth ETF 0.55
    XJH D iShares ESG Screened S&P Mid-Cap ETF 0.54
    FTXH B First Trust Nasdaq Pharmaceuticals ETF 0.52
    PWS A Pacer WealthShield ETF 0.52
    ISCB C iShares Morningstar Small-Cap ETF 0.5
    JHSC D John Hancock Multifactor Small Cap ETF 0.49
    MDY D SPDR MidCap Trust Series I 0.49
    PTMC D Pacer Trendpilot 450 ETF 0.48
    IVOO D Vanguard S&P Mid-Cap 400 ETF 0.48
    SPMD D SPDR Portfolio Mid Cap ETF 0.47
    SCHA C Schwab U.S. Small-Cap ETF 0.47
    QQQJ B Invesco NASDAQ Next Gen 100 ETF 0.46
    XT B iShares Exponential Technologies ETF 0.46
    SMDY C Syntax Stratified MidCap ETF 0.45
    PILL F Direxion Daily Pharmaceutical & Medical Bull 3X Shares ETF 0.43
    MMSC B First Trust Multi-Manager Small 0.4
    NULG A NuShares ESG Large-Cap Growth ETF 0.39
    FFSM D Fidelity Fundamental Small-Mid Cap ETF 0.39
    VFMO A Vanguard U.S. Momentum Factor ETF 0.39
    NUSC D NuShares ESG Small-Cap ETF 0.38
    VB D Vanguard Small-Cap ETF 0.37
    MVV D ProShares Ultra MidCap400 0.37
    IWM C iShares Russell 2000 ETF 0.36
    FLDZ B RiverNorth Volition America Patriot ETF 0.36
    FSMD C Fidelity Small-Mid Factor ETF 0.35
    VTWO C Vanguard Russell 2000 ETF 0.34
    UMDD D UltraPro MidCap400 0.34
    VHT B Vanguard Health Care ETF 0.34
    ISMD D Inspire Small/Mid Cap Impact ETF 0.34
    PSC C Principal U.S. Small Cap Index ETF 0.33
    SFYX D SoFi Next 500 ETF 0.33
    SCHM D Schwab U.S. Mid Cap ETF 0.33
    HART B IQ Healthy Hearts ETF 0.33
    FHLC B Fidelity MSCI Health Care Index ETF 0.33
    VXF C Vanguard Extended Market ETF 0.32
    MIDU D Direxion Mid Cap Bull 3X Shares 0.3
    FNY C First Trust Mid Cap Growth AlphaDEX 0.29
    UWM C ProShares Ultra Russell2000 0.28
    IWP B iShares Russell Midcap Growth ETF 0.28
    MDYV D SPDR S&P 400 Mid Cap Value ETF (based on S&P MidCap 400 Value Index 0.27
    QVMM D Invesco S&P MidCap 400 QVM Multi-factor ETF 0.27
    IYH A iShares U.S. Healthcare ETF 0.25
    TZA C Direxion Small Cap Bear 3X Shares 0.25
    IHE B iShares U.S. Pharmaceutical ETF 0.23
    IVOV D Vanguard S&P Mid-Cap 400 Value ETF 0.22
    SMMD D iShares Russell 2500 ETF 0.22
    ISCV D iShares Morningstar Small-Cap Value ETF 0.21
    FPXE B First Trust IPOX Europe Equity Opportunities ETF 0.2
    URTY C ProShares UltraPro Russell2000 0.19
    ESML D iShares MSCI USA Small-Cap ESG Optimized ETF 0.18
    JHMM D John Hancock Multifactor Mid Cap ETF 0.16
    PRFZ C PowerShares FTSE RAFI US 1500 Small-Mid Portfolio 0.16
    EQAL C PowerShares Russell 1000 Equal Weight Portfolio 0.14
    BKSE D BNY Mellon US Small Cap Core Equity ETF 0.14
    TPLC C Timothy Plan US Large Cap Core ETF 0.14
    EUSA C iShares MSCI USA Index Fund 0.13
    TPLE C Timothy Plan US Large/Mid Cap Core Enhanced ETF 0.13
    IWR D iShares Russell Mid-Cap ETF 0.12
    GSSC C Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF 0.11
    HKND B Humankind US Stock ETF 0.1
    EGUS A iShares ESG Aware MSCI USA Growth ETF 0.09
    ONEQ A Fidelity Nasdaq Composite Index Tracking Stock 0.09
    RYLD C Global X Russell 2000 Covered Call ETF 0.08
    EZM D WisdomTree MidCap Earnings Fund 0.08
    FAD B First Trust MuFirst Trust Multi CG AlphaDEX 0.08
    AVSC C Avantis U.S. Small Cap Equity ETF 0.07
    SUSA A iShares MSCI USA ESG Select ETF 0.07
    FTQI A First Trust Low Beta Income ETF 0.07
    KOMP D SPDR Kensho New Economies Composite ETF 0.07
    CFA C Compass EMP US 500 Volatility Weighted Index ETF 0.07
    CFO C Compass EMP US 500 Enhanced Volatility Weighted Index ETF 0.06
    JMEE D JPMorgan Market Expansion Enhanced Equity ETF 0.06
    HDG B ProShares Hedge Replication ETF 0.06
    FNX D First Trust Mid Cap Core AlphaDEX 0.06
    IWS D iShares Russell Mid-cap Value ETF 0.06
    PABU A iShares Paris-Aligned Climate MSCI USA ETF 0.06
    AVDE D Avantis International Equity ETF 0.06
    ESGV A Vanguard ESG U.S. Stock ETF 0.06
    AVSD C Avantis Responsible International Equity ETF 0.05
    JCTR A JPMorgan Carbon Transition U.S. Equity ETF 0.05
    TILT A FlexShares Mornigstar US Market Factors Tilt Index Fund ETF 0.05
    VTHR A Vanguard Russell 3000 ETF 0.05
    IWV A iShares Russell 3000 ETF 0.04
    BBSC C JPMorgan BetaBuilders U.S. Small Cap Equity ETF 0.04
    JSTC C Adasina Social Justice All Cap Global ETF 0.04
    AVSU A Avantis Responsible U.S. Equity ETF 0.04
    ITOT A iShares Core S&P Total U.S. Stock Market ETF 0.04
    IWC C iShares Microcap ETF 0.04
    IWN C iShares Russell 2000 Value ETF 0.04
    GUSA A Goldman Sachs MarketBeta U.S. 1000 Equity ETF 0.03
    VONG A Vanguard Russell 1000 Growth ETF 0.03
    USSG A Xtrackers MSCI USA ESG Leaders Equity ETF 0.03
    VTWV C Vanguard Russell 2000 Value ETF 0.03
    FNDA D Schwab Fundamental U.S. Small Company Index ETF 0.03
    RWK D RevenueShares Mid Cap 0.03
    AVUS A Avantis U.S. Equity ETF 0.03
    SCHB A Schwab U.S. Broad Market ETF 0.03
    DFAC A Dimensional U.S. Core Equity 2 ETF 0.03
    IWF A iShares Russell 1000 Growth ETF 0.03
    IUSG A iShares Core U.S. Growth ETF 0.03
    USXF B iShares ESG Advanced MSCI USA ETF 0.03
    MMTM A SPDR S&P 1500 Momentum Tilt ETF 0.03
    VT A Vanguard Total World Stock Index ETF 0.03
    DFAS D Dimensional U.S. Small Cap ETF 0.03
    ONEO C SPDR Russell 1000 Momentum Focus ETF 0.02
    JHML A John Hancock Multifactor Large Cap ETF 0.02
    JUST A Goldman Sachs JUST U.S. Large Cap Equity ETF 0.02
    SCHG A Schwab U.S. Large-Cap Growth ETF 0.02
    DFUV D Dimensional US Marketwide Value ETF 0.02
    SUSL A iShares ESG MSCI USA Leaders ETF 0.02
    IWB A iShares Russell 1000 ETF 0.02
    VONV C Vanguard Russell 1000 Value ETF 0.02
    IWD C iShares Russell 1000 Value ETF 0.02
    SPTM A SPDR Portfolio Total Stock Market ETF 0.02
    USCL A iShares Climate Conscious & Transition MSCI USA ETF 0.02
    IUSV C iShares Core U.S. Vaue ETF 0.02
    SCHK A Schwab 1000 ETF 0.02
    IYY A iShares Dow Jones U.S. ETF 0.02
    SCHX A Schwab U.S. Large-Cap ETF 0.01
    DFAI C Dimensional International Core Equity Market ETF 0.01
    DFAU A Dimensional US Core Equity Market ETF 0.01
    URTH A iShares MSCI World Index Fund 0.01
    RECS A Columbia Research Enhanced Core ETF 0.01
    PBUS A Invesco PureBeta MSCI USA ETF 0.01
    KOKU A Xtrackers MSCI Kokusai Equity ETF 0.01
    ACWI A iShares MSCI ACWI Index Fund 0.01
    DFUS A Dimensional U.S. Equity ETF 0.01
    JMOM A JPMorgan U.S. Momentum Factor ETF 0.01
    TSPA A T. Rowe Price U.S. Equity Research ETF 0.01
    DEUS C Deutsche X-trackers Russell 1000 Enhanced Beta ETF 0.01
    MFUS A PIMCO RAFI Dynamic Multi-Factor U.S. Equity ETF 0.01
    DFIC C Dimensional International Core Equity 2 ETF 0.01
    DFIV C Dimensional International Value ETF 0.01
    TOK A iShares MSCI KLD 400 Social ETF 0.01
    VLU A SPDR S&P 1500 Value Tilt ETF 0.01
    FNDB A Schwab Fundamental U.S. Broad Market Index ETF 0.0
    REVS C Columbia Research Enhanced Value ETF 0.0
    SPGM A SPDR Portfolio MSCI Global Stock Market ETF 0.0
    QUS A SPDR MSCI USA Quality Mix ETF 0.0
    CRBN A iShares MSCI ACWI Low Carbon Target ETF 0.0
    QWLD A SPDR MSCI World Quality Mix ETF 0.0
    BTAL B QuantShares U.S. Market Neutral Anti Beta Fund ETF -0.34
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