XBI vs. SBIO ETF Comparison

Comparison of SPDR S&P Biotech ETF (XBI) to ALPS Medical Breakthroughs ETF (SBIO)

XBI

SPDR S&P Biotech ETF

XBI Description

The investment seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of an index derived from the biotechnology segment of a U.S. total market composite index. In seeking to track the performance of the S&P Biotechnology Select Industry Index (the "index"), the fund employs a replication strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology industry group of the S&P Total Market Index ("S&P TMI"). The fund is non-diversified.

Grade (RS Rating)

Last Trade

$103.01

Average Daily Volume

7,051,711

Number of Holdings ^*

128

* may have additional holdings in another (foreign) market

SBIO

ALPS Medical Breakthroughs ETF

SBIO Description

The investment seeks investment results that correspond (before fees and expenses) generally to the performance of its underlying index, the Poliwogg Medical Breakthroughs IndexSM. The fund employs a "passive management" - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small- and mid-cap stocks of biotechnology and pharmaceutical companies that have one or more drugs in either Phase II or Phase III U.S. Food and Drug Administration clinical trials. It is non-diversified.

Grade (RS Rating)

Last Trade

$41.22

Average Daily Volume

6,673

Number of Holdings ^*

* may have additional holdings in another (foreign) market

Performance

Period	XBI	SBIO
30 Days	6.09%	10.46%
60 Days	6.74%	14.31%
90 Days	7.83%	19.16%
12 Months	48.60%	65.03%

52 Overlapping Holdings

Symbol	Grade	Weight in XBI	Weight in SBIO	Overlap
ACAD	D	0.63%	1.6%	0.63%
ACLX	A	0.71%	3.03%	0.71%
AGIO	A	0.6%	1.7%	0.6%
AKRO	B	0.43%	1.39%	0.43%
ALEC	C	0.05%	0.34%	0.05%
ALKS	C	1.01%	2.83%	1.01%
ALLO	C	0.13%	0.39%	0.13%
ALT	D	0.16%	0.32%	0.16%
ANAB	F	0.12%	0.41%	0.12%
ANNX	C	0.19%	0.48%	0.19%
APLT	B	0.22%	0.72%	0.22%
ARCT	F	0.17%	0.34%	0.17%
AVXL	C	0.14%	0.31%	0.14%
BCRX	C	0.47%	1.13%	0.47%
CELC	C	0.13%	0.41%	0.13%
CGON	C	0.42%	1.67%	0.42%
CLDX	F	0.35%	1.14%	0.35%
COGT	D	0.2%	0.9%	0.2%
CRNX	B	0.82%	2.89%	0.82%
DAWN	C	0.3%	0.86%	0.3%
DNLI	C	0.47%	2.43%	0.47%
ERAS	B	0.09%	0.5%	0.09%
ETNB	C	0.17%	0.55%	0.17%
FDMT	F	0.11%	0.28%	0.11%
FOLD	D	0.69%	2.24%	0.69%
GERN	D	0.87%	1.61%	0.87%
IDYA	F	0.54%	1.63%	0.54%
IMVT	D	0.67%	2.91%	0.67%
IRON	C	0.26%	0.89%	0.26%
IRWD	D	0.25%	0.42%	0.25%
ITOS	F	0.07%	0.19%	0.07%
KROS	B	0.37%	1.42%	0.37%
KRYS	C	1.2%	3.35%	1.2%
KURA	F	0.23%	0.85%	0.23%
MIRM	C	0.51%	1.24%	0.51%
MNKD	B	0.34%	1.25%	0.34%
NTLA	F	0.56%	0.93%	0.56%
OLMA	C	0.16%	0.45%	0.16%
PRTA	F	0.15%	0.64%	0.15%
PTCT	B	0.61%	2.02%	0.61%
PTGX	B	0.63%	1.8%	0.63%
RCUS	D	0.19%	0.93%	0.19%
REPL	B	0.18%	0.54%	0.18%
RNA	B	1.24%	3.25%	1.24%
SNDX	C	0.48%	1.07%	0.48%
SPRY	B	0.18%	0.86%	0.18%
SVRA	D	0.09%	0.4%	0.09%
VCEL	B	0.35%	1.44%	0.35%
VERA	B	0.51%	1.53%	0.51%
VRDN	B	0.3%	0.89%	0.3%
XNCR	C	0.2%	0.86%	0.2%
YMAB	C	0.08%	0.43%	0.08%

XBI Overweight 76 Positions Relative to SBIO

Symbol	Grade	Weight
INCY	A	3.02%
UTHR	A	2.78%
VKTX	C	2.75%
GILD	A	2.72%
EXAS	F	2.68%
ABBV	B	2.64%
ALNY	C	2.6%
NBIX	C	2.52%
SRPT	D	2.49%
NTRA	C	2.47%
VRTX	B	2.44%
AMGN	D	2.42%
INSM	D	2.3%
BIIB	F	2.24%
MDGL	B	2.12%
MRNA	F	2.01%
BMRN	F	1.98%
REGN	F	1.84%
CYTK	D	1.65%
CRSP	C	1.62%
HALO	C	1.58%
BPMC	C	1.58%
RVMD	B	1.38%
TGTX	B	1.36%
IONS	F	1.15%
ROIV	D	1.14%
ADMA	C	1.13%
EXEL	A	1.12%
IOVA	C	1.09%
PCVX	D	1.03%
BBIO	F	0.92%
TWST	C	0.86%
APLS	F	0.85%
RARE	D	0.75%
DYN	F	0.71%
BEAM	D	0.64%
RXRX	D	0.64%
SWTX	F	0.63%
NUVL	D	0.57%
ARDX	D	0.54%
JANX	C	0.53%
ARWR	D	0.52%
NVAX	F	0.52%
SRRK	C	0.49%
RYTM	B	0.47%
DVAX	C	0.46%
VCYT	B	0.46%
KYMR	B	0.45%
CPRX	B	0.4%
ARQT	C	0.36%
NRIX	B	0.34%
RCKT	F	0.33%
SMMT	C	0.31%
MYGN	F	0.3%
CGEM	F	0.27%
VIR	C	0.24%
TVTX	C	0.24%
CDNA	D	0.23%
EBS	C	0.2%
HUMA	F	0.2%
VERV	D	0.19%
SANA	F	0.18%
CDMO	B	0.17%
RLAY	F	0.16%
STOK	C	0.16%
IMNM	F	0.15%
SAGE	F	0.13%
CCCC	D	0.12%
OCGN	D	0.11%
MDXG	C	0.11%
RGNX	D	0.1%
ORIC	D	0.09%
FATE	F	0.08%
SCLX	D	0.08%
ABUS	D	0.07%
KALV	F	0.07%

XBI Underweight 31 Positions Relative to SBIO

Symbol	Grade	Weight
CORT	B	-3.19%
MRUS	B	-2.34%
XENE	B	-2.04%
EWTX	B	-1.96%
ZLAB	C	-1.96%
VRNA	B	-1.82%
LBPH	A	-1.35%
ARVN	C	-1.26%
GLPG	F	-1.22%
TARS	B	-1.12%
IMCR	D	-1.04%
PHVS	C	-0.89%
AUPH	C	-0.68%
PLRX	C	-0.59%
LQDA	C	-0.58%
MLYS	C	-0.45%
FLGT	C	-0.4%
URGN	F	-0.38%
FULC	F	-0.34%
AURA	B	-0.31%
CMPS	F	-0.28%
TBPH	C	-0.27%
GHRS	C	-0.27%
ALDX	D	-0.21%
STRO	C	-0.2%
ACIU	F	-0.19%
VNDA	C	-0.17%
INZY	F	-0.17%
ENTA	F	-0.16%
ZNTL	F	-0.13%
HLVX	D	-0.06%

SBIO: Top Represented Industries & Keywords

Industries: Biotechnology Diagnostics & Research Drug Manufacturers - Specialty & Generic Medical Care Facilities