XBI vs. IBRN ETF Comparison

Comparison of SPDR S&P Biotech ETF (XBI) to iShares Neuroscience and Healthcare ETF (IBRN)

XBI

SPDR S&P Biotech ETF

XBI Description

The investment seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of an index derived from the biotechnology segment of a U.S. total market composite index. In seeking to track the performance of the S&P Biotechnology Select Industry Index (the "index"), the fund employs a replication strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology industry group of the S&P Total Market Index ("S&P TMI"). The fund is non-diversified.

Grade (RS Rating)

Last Trade

$91.71

Average Daily Volume

8,628,055

Number of Holdings ^*

125

* may have additional holdings in another (foreign) market

IBRN

iShares Neuroscience and Healthcare ETF

IBRN Description

iShares Neuroscience and Healthcare ETF is an exchange traded fund launched by BlackRock, Inc. It is managed by BlackRock Fund Advisors. The fund invests in public equity markets of global region. It invests in stocks of companies operating across neurology biopharmaceuticals or neurological devices sectors. The fund invests in growth and value stocks of companies across diversified market capitalization. It seeks to track the performance of the NYSE FactSet Global Neuro Biopharma and MedTech Index, by using representative sampling technique. iShares Neuroscience and Healthcare ETF is domiciled in the United States.

Grade (RS Rating)

Last Trade

$23.50

Average Daily Volume

590

Number of Holdings ^*

* may have additional holdings in another (foreign) market

Performance

Period	XBI	IBRN
30 Days	-2.44%	-1.38%
60 Days	1.37%	-2.23%
90 Days	1.82%	-4.66%
12 Months	12.38%	-1.31%

14 Overlapping Holdings

Symbol	Grade	Weight in XBI	Weight in IBRN	Overlap
ACAD	C	0.69%	4.32%	0.69%
ALEC	F	0.06%	0.7%	0.06%
ALKS	C	1.04%	3.99%	1.04%
AVXL	C	0.13%	0.72%	0.13%
BIIB	C	2.62%	3.99%	2.62%
CERE	C	1.04%	3.97%	1.04%
CPRX	D	0.41%	3.13%	0.41%
DYN	B	0.72%	4.5%	0.72%
NBIX	C	2.39%	3.91%	2.39%
PRTA	F	0.28%	1.95%	0.28%
PTCT	D	0.51%	3.73%	0.51%
SRPT	C	3.31%	5.03%	3.31%
SRRK	F	0.15%	1.1%	0.15%
VYGR	F	0.1%	0.72%	0.1%

XBI Overweight 111 Positions Relative to IBRN

Symbol	Grade	Weight
UTHR	B	3.0%
ALNY	A	2.91%
GILD	C	2.89%
EXAS	D	2.86%
AMGN	B	2.84%
REGN	B	2.79%
BMRN	C	2.77%
ABBV	C	2.75%
VRTX	B	2.67%
NTRA	B	2.67%
INCY	D	2.55%
MRNA	D	2.37%
VKTX	D	2.32%
CYTK	D	1.98%
CRSP	F	1.51%
MDGL	C	1.47%
BPMC	A	1.44%
APLS	F	1.43%
IONS	B	1.18%
EXEL	C	1.14%
INSM	A	1.13%
KRYS	B	1.11%
PCVX	B	1.04%
RVMD	D	1.04%
HALO	B	1.0%
BBIO	D	0.94%
TGTX	B	0.87%
SWTX	F	0.83%
IOVA	F	0.8%
RARE	D	0.75%
NUVL	C	0.74%
NTLA	F	0.7%
TWST	B	0.7%
CRNX	D	0.69%
ACLX	C	0.67%
FOLD	C	0.65%
RNA	C	0.64%
GERN	B	0.63%
CLDX	F	0.63%
IDYA	F	0.61%
BEAM	D	0.6%
VERA	C	0.6%
ARDX	F	0.57%
ARWR	C	0.56%
IMVT	D	0.54%
SNDX	C	0.52%
RXRX	F	0.51%
NVAX	C	0.5%
DVAX	D	0.5%
AGIO	C	0.49%
DNLI	C	0.49%
JANX	D	0.45%
VCEL	C	0.44%
ADMA	B	0.44%
BCRX	B	0.42%
RYTM	B	0.42%
AKRO	C	0.41%
NRIX	C	0.41%
KYMR	D	0.4%
KURA	D	0.38%
KROS	F	0.38%
RCKT	F	0.37%
VCYT	C	0.36%
IRWD	F	0.35%
PTGX	B	0.35%
ARQT	B	0.35%
MORF	C	0.35%
MYGN	B	0.34%
MIRM	B	0.33%
FDMT	D	0.29%
DAWN	D	0.29%
ARCT	F	0.28%
MNKD	C	0.27%
XNCR	F	0.27%
VRDN	F	0.26%
SANA	F	0.26%
CGEM	D	0.25%
CGON	D	0.23%
COGT	C	0.22%
TVTX	C	0.22%
RCUS	F	0.21%
SAGE	F	0.2%
ALT	F	0.2%
IMNM	F	0.2%
SMMT	C	0.19%
CDMO	D	0.19%
VIR	F	0.19%
ANAB	B	0.18%
RLAY	F	0.18%
CDNA	B	0.18%
RGNX	F	0.17%
KNSA	C	0.16%
OLMA	D	0.16%
OCGN	C	0.15%
STOK	D	0.15%
EDIT	F	0.15%
IRON	C	0.15%
ETNB	F	0.15%
ALLO	F	0.14%
CCCC	F	0.13%
HRTX	D	0.13%
MDXG	F	0.13%
FATE	F	0.12%
SPRY	C	0.11%
VERV	F	0.11%
CABA	F	0.11%
ORIC	D	0.11%
ZNTL	F	0.1%
SVRA	C	0.08%
HUMA	D	0.08%
ITOS	D	0.08%

XBI Underweight 32 Positions Relative to IBRN

Symbol	Grade	Weight
ARGX	B	-4.65%
BHVN	F	-4.1%
ITCI	C	-4.07%
AXNX	B	-3.95%
XENE	F	-3.9%
IART	C	-3.67%
SUPN	F	-2.9%
AVDL	C	-2.68%
EWTX	B	-2.35%
SAVA	F	-1.73%
LBPH	B	-1.51%
DNTH	C	-1.04%
NMRA	D	-1.02%
WVE	C	-0.99%
PEPG	C	-0.87%
ANNX	D	-0.71%
VNDA	C	-0.66%
AXGN	B	-0.61%
NVRO	F	-0.59%
LRMR	D	-0.56%
TRDA	F	-0.53%
ANRO	D	-0.48%
SLDB	F	-0.36%
ABEO	C	-0.33%
KYTX	F	-0.29%
CAPR	D	-0.28%
CVRX	C	-0.26%
ABOS	F	-0.21%
NPCE	F	-0.2%
ATHA	C	-0.19%
AMLX	F	-0.18%
VTGN	F	-0.17%

XBI: Top Represented Industries & Keywords

Industries: Biotechnology Diagnostics & Research Drug Manufacturers - Major Drug Manufacturers - Specialty & Generic Medical Devices

IBRN: Top Represented Industries & Keywords

Industries: Biotechnology Medical Devices Drug Manufacturers - Specialty & Generic Drug Manufacturers - Major