XBI vs. CANC ETF Comparison

Comparison of SPDR S&P Biotech ETF (XBI) to Tema Oncology ETF (CANC)

XBI

SPDR S&P Biotech ETF

XBI Description

The investment seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of an index derived from the biotechnology segment of a U.S. total market composite index. In seeking to track the performance of the S&P Biotechnology Select Industry Index (the "index"), the fund employs a replication strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology industry group of the S&P Total Market Index ("S&P TMI"). The fund is non-diversified.

Grade (RS Rating)

Last Trade

$94.46

Average Daily Volume

8,345,258

Number of Holdings ^*

128

* may have additional holdings in another (foreign) market

CANC

Tema Oncology ETF

CANC Description

Under normal circumstances, the fund seeks to achieve its investment objective by investing at least 80% of its net assets, which include borrowings for investment purposes, in publicly listed companies that derive at least 50% of revenues from oncology. The fund is non-diversified.

Grade (RS Rating)

Last Trade

$26.62

Average Daily Volume

2,712

Number of Holdings ^*

* may have additional holdings in another (foreign) market

Performance

Period	XBI	CANC
30 Days	-4.22%	-6.65%
60 Days	-7.47%	-10.02%
90 Days	-6.11%	-10.36%
12 Months	30.77%	15.15%

26 Overlapping Holdings

Symbol	Grade	Weight in XBI	Weight in CANC	Overlap
ACLX	C	0.79%	1.5%	0.79%
AGIO	C	0.76%	2.71%	0.76%
AMGN	D	2.28%	2.37%	2.28%
BPMC	C	1.69%	4.05%	1.69%
CGEM	F	0.25%	0.83%	0.25%
CGON	F	0.42%	0.56%	0.42%
CLDX	D	0.34%	1.44%	0.34%
COGT	D	0.16%	0.95%	0.16%
CRSP	D	1.63%	2.3%	1.63%
DAWN	D	0.28%	1.9%	0.28%
EXAS	D	2.05%	1.45%	1.45%
EXEL	B	1.23%	2.93%	1.23%
GILD	B	2.9%	5.49%	2.9%
IDYA	F	0.53%	0.9%	0.53%
INCY	C	3.29%	4.1%	3.29%
JANX	C	0.51%	1.43%	0.51%
MRNA	F	1.57%	0.72%	0.72%
NRIX	C	0.33%	1.15%	0.33%
NTLA	F	0.58%	1.58%	0.58%
NUVL	D	0.6%	1.99%	0.6%
ORIC	F	0.09%	0.76%	0.09%
RCUS	F	0.2%	0.67%	0.2%
REGN	F	1.8%	5.25%	1.8%
RLAY	F	0.14%	0.69%	0.14%
RVMD	B	1.46%	4.6%	1.46%
SWTX	C	0.77%	2.14%	0.77%

XBI Overweight 102 Positions Relative to CANC

Symbol	Grade	Weight
NTRA	A	3.3%
UTHR	C	2.88%
NBIX	C	2.62%
VRTX	D	2.62%
INSM	C	2.43%
ALNY	D	2.38%
ABBV	F	2.33%
SRPT	F	2.28%
BIIB	F	2.19%
MDGL	C	2.17%
VKTX	F	2.0%
BMRN	F	1.98%
CYTK	D	1.79%
TGTX	B	1.62%
RNA	C	1.32%
KRYS	C	1.29%
HALO	F	1.27%
ADMA	B	1.23%
ROIV	D	1.18%
ALKS	C	1.13%
IONS	F	1.08%
TWST	F	0.93%
PCVX	D	0.9%
IOVA	F	0.88%
BBIO	F	0.87%
APLS	F	0.86%
GERN	C	0.86%
CRNX	B	0.84%
DYN	D	0.78%
ACAD	C	0.78%
BEAM	D	0.72%
RARE	F	0.69%
RXRX	D	0.66%
PTCT	B	0.64%
FOLD	F	0.63%
IMVT	F	0.62%
RYTM	C	0.61%
PTGX	D	0.58%
VERA	C	0.57%
MIRM	B	0.57%
ARWR	D	0.54%
VCYT	B	0.53%
SRRK	B	0.49%
DVAX	C	0.49%
NVAX	F	0.47%
ARDX	F	0.47%
VCEL	A	0.46%
DNLI	D	0.46%
KYMR	D	0.45%
SNDX	F	0.44%
AKRO	C	0.43%
ARQT	B	0.42%
BCRX	D	0.42%
CPRX	C	0.41%
KROS	D	0.36%
IRON	B	0.34%
MNKD	B	0.34%
SMMT	D	0.33%
VRDN	D	0.3%
RCKT	F	0.28%
MYGN	F	0.27%
IRWD	F	0.26%
TVTX	C	0.26%
CDNA	D	0.24%
KURA	F	0.24%
XNCR	B	0.24%
APLT	B	0.22%
CDMO	A	0.22%
VIR	F	0.2%
EBS	C	0.2%
REPL	C	0.18%
HUMA	F	0.18%
ALT	C	0.18%
SPRY	C	0.18%
AVXL	B	0.17%
ARCT	F	0.17%
ANNX	F	0.16%
STOK	D	0.16%
ETNB	D	0.16%
MDXG	B	0.16%
VERV	D	0.15%
OLMA	F	0.13%
IMNM	F	0.13%
PRTA	F	0.13%
OCGN	F	0.12%
ANAB	F	0.12%
FDMT	F	0.12%
SANA	F	0.12%
RGNX	D	0.12%
ALLO	F	0.11%
CELC	F	0.11%
SAGE	F	0.11%
CCCC	F	0.1%
ERAS	C	0.1%
FATE	F	0.08%
SVRA	F	0.08%
ABUS	D	0.07%
KALV	F	0.07%
SCLX	F	0.06%
YMAB	F	0.06%
ITOS	F	0.06%
ALEC	F	0.04%

XBI Underweight 17 Positions Relative to CANC

Symbol	Grade	Weight
ARGX	A	-4.19%
ILMN	C	-4.16%
MRK	F	-2.81%
MREO	F	-2.54%
BGNE	D	-2.3%
GH	B	-2.07%
NVS	D	-2.03%
GMAB	F	-1.84%
SDGR	C	-1.44%
LEGN	D	-1.41%
MRUS	F	-1.37%
LNTH	C	-1.22%
BNTX	D	-0.89%
BCYC	F	-0.84%
IMCR	C	-0.69%
TERN	F	-0.6%
ARVN	F	-0.46%

CANC: Top Represented Industries & Keywords

Industries: Biotechnology Diagnostics & Research Drug Manufacturers - Major Health Information Services Long-Term Care Facilities