XBI vs. BBC ETF Comparison

Comparison of SPDR S&P Biotech ETF (XBI) to Virtus LifeSci Biotech Clinical Trials ETF (BBC)

XBI

SPDR S&P Biotech ETF

XBI Description

The investment seeks to provide investment results that, before fees and expenses, correspond generally to the total return performance of an index derived from the biotechnology segment of a U.S. total market composite index. In seeking to track the performance of the S&P Biotechnology Select Industry Index (the "index"), the fund employs a replication strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology industry group of the S&P Total Market Index ("S&P TMI"). The fund is non-diversified.

Grade (RS Rating)

Last Trade

$99.27

Average Daily Volume

6,763,174

Number of Holdings ^*

128

* may have additional holdings in another (foreign) market

BBC

Virtus LifeSci Biotech Clinical Trials ETF

BBC Description

The Fund seeks investment results that correspond, before fees and expenses, to the price and yield performance of the LifeSci Biotechnology Clinical Trials Index, which tracks the performance of select clinical trials stage biotechnology companies.

Grade (RS Rating)

Last Trade

$28.79

Average Daily Volume

1,746

Number of Holdings ^*

101

* may have additional holdings in another (foreign) market

Performance

Period	XBI	BBC
30 Days	1.20%	4.40%
60 Days	-1.95%	2.74%
90 Days	2.92%	6.26%
12 Months	45.66%	57.34%

62 Overlapping Holdings

Symbol	Grade	Weight in XBI	Weight in BBC	Overlap
ABUS	D	0.07%	1.01%	0.07%
ACLX	B	0.75%	1.22%	0.75%
AKRO	A	0.4%	0.92%	0.4%
ALEC	D	0.05%	0.74%	0.05%
ALLO	D	0.13%	0.79%	0.13%
ANAB	F	0.21%	1.05%	0.21%
ANNX	B	0.2%	0.98%	0.2%
APLT	A	0.22%	1.34%	0.22%
ARCT	F	0.2%	0.47%	0.2%
ARQT	D	0.35%	0.71%	0.35%
ARWR	F	0.54%	0.59%	0.54%
BEAM	F	0.62%	0.69%	0.62%
CELC	D	0.14%	0.81%	0.14%
CGEM	F	0.27%	0.57%	0.27%
CGON	F	0.43%	0.83%	0.43%
CLDX	F	0.4%	0.61%	0.4%
COGT	B	0.21%	1.05%	0.21%
CRNX	B	0.87%	0.99%	0.87%
CYTK	F	1.73%	0.78%	0.78%
DNLI	C	0.47%	0.94%	0.47%
DYN	F	0.82%	0.73%	0.73%
ERAS	C	0.09%	0.93%	0.09%
ETNB	D	0.15%	0.66%	0.15%
FDMT	F	0.12%	0.26%	0.12%
IDYA	F	0.57%	0.59%	0.57%
IMNM	F	0.15%	0.59%	0.15%
IMVT	F	0.7%	0.9%	0.7%
IRON	D	0.26%	0.93%	0.26%
ITOS	F	0.07%	0.42%	0.07%
JANX	A	0.52%	0.99%	0.52%
KROS	A	0.36%	0.95%	0.36%
KURA	F	0.24%	0.65%	0.24%
KYMR	C	0.49%	1.1%	0.49%
NRIX	B	0.35%	1.19%	0.35%
NTLA	F	0.78%	0.48%	0.48%
NUVL	D	0.61%	0.93%	0.61%
OLMA	F	0.16%	0.74%	0.16%
ORIC	D	0.09%	0.87%	0.09%
PCVX	C	1.1%	1.19%	1.1%
PRTA	F	0.16%	0.6%	0.16%
PTGX	B	0.64%	1.08%	0.64%
RCKT	F	0.35%	0.59%	0.35%
RCUS	F	0.22%	0.83%	0.22%
REPL	B	0.19%	1.0%	0.19%
RGNX	F	0.11%	0.58%	0.11%
RLAY	F	0.17%	0.62%	0.17%
RNA	C	1.38%	0.89%	0.89%
RVMD	A	1.24%	0.94%	0.94%
RXRX	F	0.65%	0.53%	0.53%
SANA	F	0.19%	0.42%	0.19%
SCLX	D	0.08%	0.12%	0.08%
SMMT	C	0.33%	1.9%	0.33%
SNDX	F	0.49%	0.72%	0.49%
SRRK	B	0.49%	2.42%	0.49%
STOK	C	0.15%	0.54%	0.15%
SVRA	D	0.09%	0.65%	0.09%
VERA	A	0.48%	0.84%	0.48%
VERV	C	0.18%	0.8%	0.18%
VIR	B	0.2%	0.56%	0.2%
VKTX	A	2.34%	1.11%	1.11%
VRDN	B	0.32%	1.4%	0.32%
XNCR	A	0.21%	0.78%	0.21%

XBI Overweight 66 Positions Relative to BBC

Symbol	Grade	Weight
ALNY	C	2.87%
EXAS	A	2.77%
GILD	A	2.72%
UTHR	A	2.69%
SRPT	D	2.69%
INCY	A	2.65%
ABBV	A	2.5%
VRTX	D	2.5%
INSM	D	2.49%
AMGN	C	2.45%
NBIX	C	2.43%
BIIB	F	2.42%
NTRA	B	2.42%
BMRN	F	2.13%
REGN	F	2.11%
MRNA	F	2.02%
BPMC	C	1.51%
CRSP	C	1.5%
HALO	B	1.44%
MDGL	A	1.38%
KRYS	C	1.21%
TGTX	A	1.2%
IONS	F	1.17%
ROIV	D	1.16%
ALKS	F	1.09%
IOVA	B	0.98%
EXEL	A	0.96%
ADMA	B	0.94%
BBIO	D	0.91%
GERN	C	0.88%
TWST	F	0.87%
APLS	F	0.84%
RARE	D	0.82%
FOLD	B	0.71%
PTCT	B	0.66%
ACAD	F	0.62%
AGIO	B	0.61%
SWTX	D	0.6%
NVAX	F	0.57%
ARDX	D	0.51%
MIRM	B	0.5%
RYTM	D	0.48%
BCRX	A	0.46%
VCYT	A	0.45%
DVAX	A	0.44%
CPRX	A	0.4%
MYGN	F	0.38%
VCEL	D	0.35%
MNKD	A	0.31%
DAWN	A	0.3%
TVTX	B	0.25%
CDNA	D	0.24%
IRWD	F	0.24%
HUMA	D	0.22%
SPRY	B	0.2%
EBS	B	0.19%
CDMO	C	0.18%
SAGE	F	0.17%
ALT	D	0.16%
CCCC	F	0.13%
OCGN	F	0.11%
AVXL	A	0.11%
MDXG	C	0.1%
FATE	F	0.1%
YMAB	A	0.08%
KALV	D	0.08%

XBI Underweight 39 Positions Relative to BBC

Symbol	Grade	Weight
LBPH	A	-2.35%
WVE	B	-1.8%
IGMS	B	-1.57%
EWTX	B	-1.52%
CNTA	A	-1.23%
TYRA	F	-1.14%
SAVA	D	-1.08%
BLTE	A	-1.05%
ELVN	B	-1.04%
QURE	B	-0.97%
PHVS	A	-0.93%
PLRX	A	-0.9%
XENE	C	-0.87%
MLYS	B	-0.85%
BCYC	D	-0.8%
ARVN	C	-0.8%
AUTL	D	-0.77%
CMPS	F	-0.73%
SLN	F	-0.72%
MRUS	C	-0.71%
TERN	D	-0.67%
LRMR	C	-0.65%
LQDA	C	-0.65%
ABCL	C	-0.64%
NUVB	F	-0.61%
MGNX	C	-0.61%
IMTX	F	-0.58%
CVAC	F	-0.54%
EDIT	F	-0.46%
PGEN	F	-0.42%
PRME	C	-0.42%
TSHA	F	-0.37%
FULC	F	-0.33%
LYEL	F	-0.33%
ZNTL	D	-0.26%
CABA	F	-0.24%
ALXO	F	-0.14%
HLVX	C	-0.1%
AVTE	C	-0.07%