HRTS vs. MEDX ETF Comparison

Comparison of Tema Cardiovascular and Metabolic ETF (HRTS) to Horizon Kinetics Medical ETF (MEDX)

HRTS

Tema Cardiovascular and Metabolic ETF

HRTS Description

Under normal circumstances, the fund seeks to achieve its investment objective by investing at least 80% of its net assets, which include borrowings for investment purposes, in publicly listed companies that derive at least 50% of revenues from products or services related to the treatment of cardiovascular diseases and/or metabolic diseases, as defined by the Centers for Diseases Control and Preventions. The fund advisor generally is expected to consist of more than 15 companies but not more than 100 companies. The fund is non-diversified.

Grade (RS Rating)

Last Trade

$34.93

Average Daily Volume

25,322

Number of Holdings ^*

8

* may have additional holdings in another (foreign) market

MEDX

Horizon Kinetics Medical ETF

MEDX Description

The fund is an actively-managed exchange-traded fund ("ETF") that pursues its investment objective by investing, under normal circumstances, at least 80% of its net assets plus any borrowings for investment purposes in common stocks, convertible securities, warrants and other equity securities having the characteristics of common stocks of U.S. and foreign companies engaged in medical research, pharmaceutical and medical technology industries and related technology industries. The fund is non-diversified.

Grade (RS Rating)

Last Trade

$31.39

Average Daily Volume

334

Number of Holdings ^*

10

* may have additional holdings in another (foreign) market

Performance

Period	HRTS	MEDX
30 Days	2.65%	0.85%
60 Days	2.29%	3.86%
90 Days	8.35%	7.08%
12 Months		4.02%

3 Overlapping Holdings

	Symbol	Grade	Weight in HRTS	Weight in MEDX	Overlap
	ALNY	C	5.3%	4.35%	4.35%
	AMGN	B	7.09%	5.86%	5.86%
	LLY	C	5.52%	16.63%	5.52%

HRTS Overweight 5 Positions Relative to MEDX

	Symbol	Grade	Weight
	VRTX	C	4.45%
	NVO	C	4.43%
	BBIO	D	4.07%
	RARE	B	3.47%
	CYTK	D	3.32%

HRTS Underweight 7 Positions Relative to MEDX

	Symbol	Grade	Weight
	ABBV	B	-7.89%
	NVS	B	-6.09%
	AZN	D	-5.74%
	BMY	C	-4.65%
	REGN	C	-4.47%
	JNJ	B	-4.42%
	MRK	D	-4.16%

HRTS: Top Represented Industries & Keywords

Industries: Biotechnology Drug Manufacturers - Major

Keywords: Biopharmaceutical Amyloid Biotechnology Clinical Development Life Sciences Neuroscience Obesity Pharmaceutical Products S&P 500 Amyloidosis Cholesterol Diabetes Dysfunction Growth Hormone Hyperplasia IBD 50 Inflammation Monoclonal Antibody Myopathy Nasdaq 100

MEDX: Top Represented Industries & Keywords

Industries: Drug Manufacturers - Major Biotechnology

Keywords: S&P 500 Pharmaceutical Products Biotechnology Cholesterol Depressive Disorder Infectious Diseases Neuroscience Animal Health Antibiotics Biopharmaceutical Diabetes Dow Jones Component Drugs Hypertension Infection Inflammation Medicine Nasdaq 100 Obesity Ophthalmology